{"id":4810,"date":"2020-08-20T20:26:14","date_gmt":"2020-08-20T11:26:14","guid":{"rendered":"http:\/\/blog.sizen-kankyo.com\/blog\/?p=4810"},"modified":"2020-08-20T20:35:42","modified_gmt":"2020-08-20T11:35:42","slug":"%e3%81%aa%e3%81%9c%e5%ad%90%e3%81%a9%e3%82%82%e3%81%9f%e3%81%a1%e3%81%ae%e9%aa%a8%e6%8a%98%e3%81%8c%e6%80%a5%e6%bf%80%e3%81%ab%e5%a2%97%e3%81%88%e3%81%a6%e3%81%84%e3%82%8b%e3%81%ae%e3%81%8b","status":"publish","type":"post","link":"http:\/\/blog.sizen-kankyo.com\/blog\/2020\/08\/4810.html","title":{"rendered":"\u306a\u305c\u5b50\u3069\u3082\u305f\u3061\u306e\u9aa8\u6298\u304c\u6025\u6fc0\u306b\u5897\u3048\u3066\u3044\u308b\u306e\u304b"},"content":{"rendered":"

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\n<\/p>\n

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\u7834\u9aa8\u7d30\u80de\u3068\u306f\u3001\u9aa8\u306e\u518d\u69cb\u7bc9\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u9aa8\u3092\u7834\u58ca\uff08\u9aa8\u5438\u53ce\uff09\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u7d30\u80de\u3002<\/span><\/p>\n

\u7834\u9aa8\u7d30\u80de\u306f\u9aa8\u57fa\u8cea\u3092\u6eb6\u304b\u3057\u3066\u5438\u53ce\u3059\u308b\u3002<\/span><\/p>\n

\u5177\u4f53\u7684\u306b\u306f\u5468\u308a\u306b\u30b3\u30e9\u30b2\u30ca\u30fc\u30bc\u3084\u6c34\u7d20\u30a4\u30aa\u30f3\u3001\u305d\u306e\u307b\u304b\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u653e\u51fa\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u3084\u30ab\u30eb\u30b7\u30a6\u30e0\u5869\u7d50\u6676\u306e\u878d\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/span>\uff08\u7834\u9aa8\u7d30\u80de<\/a>\uff09<\/span><\/p><\/blockquote>\n

\u7834\u58ca\u3059\u308b\u3068\u3044\u3046\u3088\u308a\u300c\u9aa8\u306e\u57fa\u672c\u7684\u306a\u6210\u5206\u3092\u6eb6\u304b\u3057\u3066\u3057\u307e\u3046\u300d\u3082\u306e\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u7834\u9aa8\u7d30\u80de\u304c\u300c\u4f4e\u9178\u7d20\u72b6\u614b\u306b\u3088\u308a\u51fa\u73fe\u304c\u523a\u6fc0\u3055\u308c\u308b\u300d\u3088\u3046\u306a\u306e\u3067\u3059\u306d\u3002\u4ee5\u4e0b\u306f\u3001 PubMed \u306b\u3042\u3063\u305f\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u3067\u3001\u767a\u8868\u5e74\u306f 2003\u5e74\u3068\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u304b\u306a\u308a\u4ee5\u524d\u304b\u3089\u308f\u304b\u3063\u3066\u3044\u305f\u3053\u3068\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u30fb\u4f4e\u9178\u7d20\u306f\u7834\u9aa8\u7d30\u80de\u5f62\u6210\u3068\u9aa8\u5438\u53ce\u306e\u4e3b\u8981\u306a\u523a\u6fc0\u56e0\u5b50\u3068\u306a\u308b<\/span>\u00a0\uff08PubMed 2003\/07\uff09<\/span>
\nHypoxia is a major stimulator of osteoclast formation and bone resorption<\/a><\/p>\n

\u3053\u308c\u306f\u30de\u30a6\u30b9\u306b\u3088\u308b\u5b9f\u9a13\u3067\u3001\u5927\u6c17\u30ec\u30d9\u30eb\u304b\u3089\u9178\u7d20\u306e\u72b6\u614b\u3092\u4e0b\u3052\u3066\u3044\u304f\u3068\u3001\u7834\u9aa8\u7d30\u80de\u306e\u5f62\u6210\u304c\u523a\u6fc0\u3055\u308c\u3001\u9aa8\u304c\u7834\u58ca\u3055\u308c\u3066\u3044\u304f\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u306e\u3060\u305d\u3046\u3067\u3059\u3002<\/p>\n

\u3082\u3061\u308d\u3093\u3001\u5b9f\u9a13\u3067\u3059\u306e\u3067\u3001\u9178\u7d20\u306e\u4e0b\u3052\u65b9\u306f 20%\u306a\u3069\u304b\u306a\u308a\u5927\u304d\u3044\u306e\u3067\u3059\u304c\u3001\u3057\u304b\u3057\u30017\u65e5\u9593\u307b\u3069\u3067\u9aa8\u306e\u7834\u58ca\u306e\u9032\u884c\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3088\u3046\u3067\u3059\u306e\u3067\u3001\u591a\u5c11\u306e\u4f4e\u9178\u7d20\u72b6\u614b\u3067\u3082\u3001\u9577\u671f\u9593\u7d9a\u3044\u305f\u5834\u5408\u306f\u3001\u7834\u9aa8\u7d30\u80de\u306e\u751f\u6210\u306e\u523a\u6fc0\u3068\u95a2\u4fc2\u3057\u3066\u304f\u308b\u53ef\u80fd\u6027\uff08\u9aa8\u304c\u7834\u58ca\u3055\u308c\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\uff09<\/span>\u304c\u3042\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u6bd4\u8f03\u7684\u3057\u3063\u304b\u308a\u3057\u305f\u30de\u30b9\u30af\u3092\u6bce\u65e5\u9577\u6642\u9593\u7740\u7528\u3057\u3066\u3044\u308b\u5834\u5408\u306a\u3069\u3001\u671f\u9593\u304c\u9577\u304f\u306a\u3063\u305f\u5834\u5408\u3001\u9aa8\u304c\u8106\u304f\u306a\u308b\u3068\u3044\u3046\u5f71\u97ff\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\u3088\u3046\u306b\u3082\u601d\u3044\u307e\u3059\u3002\u3059\u3067\u306b\u3001\u30de\u30b9\u30af\u751f\u6d3b\u3082\u6570\u30ab\u6708\u306b\u53ca\u3093\u3067\u3044\u307e\u3059\u3057\u3001\u7740\u7528\u72b6\u6cc1\uff08\u5bb6\u3067\u3082\u305a\u3063\u3068\u3057\u3066\u3044\u308b\u306a\u3069\uff09\u306b\u3088\u3063\u3066\u306f\u3001\u9aa8\u306b\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u3082\u3046\u3072\u3068\u3064\u306f\u3001\u300c\u9178\u7d20\u305d\u306e\u3082\u306e\u304c\u3001\u9aa8\u306e\u5f62\u6210\u306b\u975e\u5e38\u306b\u91cd\u8981\u300d<\/span>\u3060\u3068\u3044\u3046\u70b9\u3067\u3059\u3002<\/p>\n

\u4ee5\u4e0b\u306f\u30012010\u5e745\u6708\u306e\u8ad6\u6587\u3067\u3059\u3002<\/p>\n

\u30fb\u4f4e\u9178\u7d20\u3001\u8ee2\u5199\u56e0\u5b50\u304a\u3088\u3073\u9aa8\u306e\u767a\u9054<\/span>\u00a0\uff08PMC 2010\/05\/02\uff09<\/span>
\nHypoxia, HIFs and bone development<\/a><\/p>\n

\u3053\u306e\u8ad6\u6587\u306f\u3068\u3066\u3082\u96e3\u3057\u304f\u3001\u79c1\u306b\u5168\u4f53\u306f\u7406\u89e3\u3067\u304d\u306a\u3044\u3067\u3059\u304c\u3001\u3053\u306e\u6982\u8981\u306e\u5192\u982d\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002<\/p>\n

\u8fd1\u5e74\u3001\u9178\u7d20\u306f\u660e\u3089\u304b\u306b\u91cd\u8981\u306a\u57fa\u8cea\u3067\u3042\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u8abf\u7bc0\u30b7\u30b0\u30ca\u30eb\u3067\u3082\u3042\u308b\u3053\u3068\u304c\u307e\u3059\u307e\u3059\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u4f4e\u9178\u7d20\u307e\u305f\u306f\u9178\u7d20\u306e\u5229\u7528\u306e\u6e1b\u5c11\u6027\u306f\u3001\u865a\u8840\u307e\u305f\u306f\u816b\u760d\u5f62\u6210\u7b49\u306e\u75c5\u7406\u5b66\u7684\u72b6\u614b\u3001\u305d\u3057\u3066\u8eab\u4f53\u306e\u6b63\u5e38\u306a\u767a\u9054\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u6709\u3059\u308b\u8ee2\u5199\u5fdc\u7b54\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002<\/span><\/p><\/blockquote>\n

\u4f4e\u9178\u7d20\u72b6\u614b\u306f\u3001\u300c\u3044\u308d\u3044\u308d\u306a\u75c5\u6c17\u306e\u767a\u73fe\u3068\u95a2\u4fc2\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u3092\u51fa\u3059\u300d\u3068\u3044\u3046\u3053\u3068\u306e\u3088\u3046\u3067\u3001\u305d\u306e\u4e2d\u306b\u3001\u300c\u9178\u7d20\u3068\u8edf\u9aa8\u300d\u3068\u3044\u3046\u3053\u3068\u306b\u3064\u3044\u3066\u3075\u308c\u3089\u308c\u3066\u3044\u308b\u90e8\u5206\u304c\u3042\u308a\u3001\u9aa8\u306e\u5916\u5074\u3068\u3044\u3046\u3088\u308a\u3001\u300c\u9178\u7d20\u306f\u8edf\u9aa8\u3084\u9aa8\u306e\u5185\u90e8\u306e\u751f\u6210\u3068\u5f37\u304f\u95a2\u4fc2\u3059\u308b\u300d\u3088\u3046\u306a\u306e\u3067\u3059\u306d\u3002<\/p>\n

\u3044\u305a\u308c\u306b\u3057\u307e\u3057\u3066\u3082\u3001<\/p>\n

\u300c\u4f4e\u9178\u7d20\u72b6\u614b\u306f\u9aa8\u306b\u826f\u304f\u306a\u3044\u300d<\/span><\/p>\n

\u3068\u3044\u3046\u3053\u3068\u306f\u65ad\u8a00\u3057\u3066\u3044\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u305d\u3057\u3066\u3001\u6b21\u306b\u3001\u3053\u308c\u3082\u5f53\u7136\u306e\u3088\u3046\u306a\u6c17\u304c\u3059\u308b\u306e\u3067\u3059\u304c\u3001<\/p>\n

\u300c\u592a\u967d\u5149\u4e0d\u8db3\u306f\u9aa8\u3092\u8106\u304f\u3059\u308b\u300d<\/span><\/p>\n

\u3053\u3068\u304c\u8ff0\u3079\u3089\u308c\u3066\u3044\u308b\u8ad6\u6587\u3082\u591a\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u306f\u3001\u4e3b\u306b\u300c\u30d3\u30bf\u30df\u30f3D\u3068\u9aa8\u300d\u306e\u95a2\u4fc2\u6027\u306e\u3088\u3046\u3067\u3059\u304c\u3001\u3053\u3061\u3089\u306e\u8ad6\u6587<\/a>\u306a\u3069\u306b\u3088\u308c\u3070\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u306f\u52b9\u679c\u304c\u4f4e\u3044\u3088\u3046\u3067\u3001\u9aa8\u5f62\u6210\u306b\u95a2\u3057\u3066\u306f\u3001\u592a\u967d\u5149\u3078\u306e\u66dd\u9732\u306b\u3088\u308a\u4f5c\u3089\u308c\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u307b\u3046\u304c\u3044\u3044\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u7d50\u5c40\u306e\u3068\u3053\u308d\u3001<\/p>\n

\u30fb\u4f4e\u9178\u7d20\uff08\u9577\u6642\u9593\u306e\u30de\u30b9\u30af\uff09<\/span><\/p>\n

\u30fb\u65e5\u5149\u306e\u4e0d\u8db3<\/span><\/p>\n

\u30fb\u904e\u5270\u306a\u6d88\u6bd2\u306b\u3088\u308b\u5e38\u5728\u83cc\u3001\u7279\u306b\u8178\u5185\u7d30\u83cc\u74b0\u5883\u306e\u5909\u5316<\/span><\/p>\n

\u306f\u3001\u3069\u308c\u3082\u9aa8\u306b\u3068\u3063\u3066\u306f\u826f\u304f\u306a\u3044\u3053\u3068\u306e\u3088\u3046\u306a\u306e\u3067\u3059\u306d\u3002<\/p>\n

\u305d\u3057\u3066\u3001\u5f53\u7136\u306a\u304c\u3089\u3001\u300c\u305d\u306e\u3088\u3046\u306a\u671f\u9593\u304c\u9577\u5f15\u3051\u3070\u9577\u5f15\u304f\u307b\u3069\u3001\u5f71\u97ff\u306f\u5f37\u304f\u306a\u308b\u300d<\/span>\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u4eca\u56de\u306f\u5192\u982d\u306b\u5b50\u3069\u3082\u306e\u9aa8\u6298\u306b\u3064\u3044\u3066\u53d6\u308a\u4e0a\u3052\u307e\u3057\u305f\u3051\u308c\u3069\u3001\u3053\u308c\u306f\u3059\u3079\u3066\u306e\u4e16\u4ee3\u3067\u540c\u3058\u3060\u3068\u3082\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u7279\u306b\u3001\u305f\u3060\u3067\u3055\u3048\u9aa8\u304c\u8106\u304f\u306a\u308a\u3084\u3059\u3044\u9ad8\u9f62\u8005\u306e\u65b9\u3005\u306f\u3001\u4eca\u5f8c\u3001\u9aa8\u306e\u72b6\u614b\u306b\u95a2\u3057\u3066\u3001\u53b3\u3057\u3044\u5c40\u9762\u306b\u81f3\u308b\u65b9\u3082\u3044\u3089\u3063\u3057\u3083\u3089\u306a\u3044\u3068\u306f\u8a00\u3048\u306a\u3044\u6c17\u3082\u3044\u305f\u3057\u307e\u3059\u3002\u9aa8\u7c97\u9b06\u75c7\u3082\u304b\u306a\u308a\u5897\u52a0\u3057\u305d\u3046\u3067\u3059\u3002<\/p>\n

\u305d\u308c\u306b\u3057\u3066\u3082\u3001\u4e0a\u306e\uff13\u3064\u3092\u898b\u3066\u898b\u307e\u3059\u3068\u3001\u7d50\u5c40\u300c\u4eca\u306e\u4e16\u754c\u306e\u751f\u6d3b\u300d\u306f\u3001\u79c1\u305f\u3061\u4eba\u9593\u304c\u9577\u3044\u9593\u3001\u3054\u304f\u666e\u901a\u3068\u3057\u3066\u304d\u305f\u3001\u305d\u3057\u3066\u3001\u305d\u308c\u306f\u4eba\u985e\u3068\u3044\u3046\u751f\u7269\u7a2e\u306b\u5fc5\u8981\u3060\u3063\u305f\u4ee5\u4e0b\u306e\uff13\u70b9\u304c\u5426\u5b9a\u3055\u308c\u3066\u3044\u308b<\/span>\u751f\u6d3b\u3067\u3059\u3002<\/p>\n

\u73fe\u5728\u5426\u5b9a\u3055\u308c\u3066\u3044\u308b\u3053\u3068<\/span><\/span><\/p>\n

\u30fb\u9178\u7d20\u306e\u591a\u3044\u304d\u308c\u3044\u306a\u7a7a\u6c17\u3092\u305f\u3063\u3077\u308a\u3068\u5438\u3046\u751f\u6d3b<\/span><\/p>\n

\u30fb\u305f\u304f\u3055\u3093\u306e\u592a\u967d\u5149\u3092\u6d74\u3073\u3066\u751f\u304d\u308b\u751f\u6d3b<\/span><\/p>\n

\u30fb\u4f53\u5185\u306e\u5e38\u5728\u83cc\u3068\u5171\u5b58\u3057\u3066\u81ea\u7136\u306e\u4e2d\u306e\u751f\u7269\u7a2e\u3068\u3057\u3066\u751f\u304d\u308b\u3053\u3068<\/span><\/p><\/blockquote>\n

\u3053\u308c\u3089\u3092\u300c\u534a\u5f37\u5236\u7684\u306b\u3064\u3076\u3055\u308c\u3066\u3044\u308b\u300d\u308f\u3051\u3067\u3059\u306e\u3067\u3001\u305d\u308a\u3083\u307e\u3042\u3001\u793e\u4f1a\u5168\u4f53\u306e\u5065\u5eb7\u72b6\u614b\u304c\u826f\u304f\u306a\u308b\u308f\u3051\u304c\u306a\u3044\u3067\u3059\u3088\u306d\u3002<\/p>\n

\u30e1\u30eb\u30de\u30ac\u306b\u66f8\u3044\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u4eca\u5f8c\u3055\u3089\u306b\u793e\u4f1a\u5168\u4f53\u306e\u5065\u5eb7\u72b6\u614b\u306f\u60aa\u5316\u3057\u3066\u3044\u304f\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

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